In New Thunderbolts #16 (2005 Series) the Radioactive Man squares off against Hyperion with horrifying results. This dust-em-up fight scene is a fun couple of panels that evoked in me warm Silver Age-y feelings of DC and fond memories of reading old comics that featured the Kryptonite Man/Kid fighting Superman/Boy.
The old Avengers vs. Squadron stories were good nudge-nudge-wink-winks for the fans (like me) who desperately wanted to see a story that featured the Avengers and the JLA but would have had to wait a few decades for it to actually happen in reality.
What caused a cringe from me was that the Radioactive Man didn't just zap Hyperion. No, that was not good enough. Instead of just pointing and shooting the RM grabs a big handful of Hyper-Package and gives Skippy the whipping to end all whippings. This date did not have a happy ending.
Hyperion is all but invulnerable but I understand the soul-rending GYYYAAAAGH! He got lit up from inside out via a billion rads surging through his Hyper-Testes. He got hurt so bad even his word balloon is radioactive! In that one inarticulate word Hyperion screamed as he watched all his futures end. No more wild get-away weekends with Power Princess in the Doctor Prism Inn, no Hyper-Children flying around being zany and giving away secret identities to the townies and worst of all...definitely no more urinating from a standing position.